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Effects of Phytohaemagglutinin on Homograft Rejection

Nature volume 216, pages 182–184 (1967)Cite this article

Abstract

ALTHOUGH phytohaemagglutinin (PHA) has been widely-investigated in vitro, relatively little is known about its effects in vivo1. It has been used in humans with aplastic anaemia, who subsequently showed evidence of increased bone marrow activity in some cases2. Gamble3 found that intravenous injection of PHA in mice resulted in increases in the cellularity, the proportion of immature cells, and the weight of the spleen, which were most marked 3 days after administration. Calne et al.4 used combined PHA and azathioprine (‘Imuran’) therapy in an attempt to prolong the survival times of renal homotransplants in dogs. Intravenous PHA potentiated the immunosuppressive action of azathioprine and was thought to have some immunosuppressive activity when used alone.

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Authors and Affiliations

  1. Eppley Research Institute and Department of Medicine, University of Nebraska College of Medicine, Omaha, Nebraska

    BRENT KHEN & PERRY RIGBY

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  1. BRENT KHEN
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  2. PERRY RIGBY
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KHEN, B., RIGBY, P. Effects of Phytohaemagglutinin on Homograft Rejection. Nature 216, 182–184 (1967). https://doi.org/10.1038/216182b0

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  • DOI: https://doi.org/10.1038/216182b0

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