Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Effects of Anti-thymocyte Serum on 17-D Yellow Fever Infection in Adult Mice

Nature volume 216, pages 179–180 (1967)Cite this article

Abstract

MANY neurotropic viral infections are accompanied by inflammatory cellular infiltrates of the central nervous system. With some of these viruses, notably lymphocytic choriomeningitis (LCM), the cellular response is believed to be responsible for the morbidity and mortality associated with infection1, and suppression of the lymphocytic response by treatment with anti-thymocyte serum prevents clinical signs of disease2,3. Yellow fever infection caused by the 17-D virus in mice is characterized by a diffuse encephalomyelitis consisting of mononuclear cell infiltration of leptomeninges and perivascular areas, as well as neuronal degeneration and glial proliferation4. We have used rabbit anti-mouse thymocyte (RAMT) serum to prevent cellular responsiveness to 11-D virus, in order to evaluate the role of delayed hypersensitivity in the pathogenesis of experimental yellow fever.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Hotchin, J., Cold Spring Harbor Symp. Quant. Biol., 27, 479 (1962).

    Article  CAS  Google Scholar 

  2. Hirsch, M. S., Murphy, F. A., Russe, H. P., and Hicklin, M. D., Proc. Soc. Exp. Biol. and Med., 125, 980 (1967).

    Article  CAS  Google Scholar 

  3. Gledhill, A. W., Nature, 214, 178 (1967).

    Article  ADS  CAS  Google Scholar 

  4. Dominguez, A. C., and Baruch, E., Amer. J. Trop. Med. and Hyg., 12, 815 (1963).

    Article  CAS  Google Scholar 

  5. Levey, R. H., and Medawar, P. B., Proc. US Nat. Acad. Sci., 56, 1130 (1966).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Health, Education and Welfare, US Public Health Service, National Communicable Disease Center, Atlanta, Georgia

    M. S. HIRSCH & F. A. MURPHY

Authors
  1. M. S. HIRSCH
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. A. MURPHY
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

HIRSCH, M., MURPHY, F. Effects of Anti-thymocyte Serum on 17-D Yellow Fever Infection in Adult Mice. Nature 216, 179–180 (1967). https://doi.org/10.1038/216179a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/216179a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing