Abstract
IT is characteristic of mixed cerebrospinal fluid, sampled in the steady state, that the concentration of glucose is deficient compared with plasma. Yet the fluid appears grossly to be neither a source nor a sink in relation to the sugar in the brain because regional differences in concentration have not been disclosed by successive sampling1, or by analyses of fluids taken from several sites2. In unsteady conditions after elevation of plasma glucose3, or during ventriculo-cisternal perfusion with an initially glucose free solution4, the flow of glucose into the system is by a facilitated mechanism and at a rate faster than could be accounted for by the contribution through choroid plexuses. Thus the concentration of glucose in fluid might be rapidly imposed by the brain if new fluid were formed with a composition different from that of mixed fluid.
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SADLER, K., WELCH, K. Concentration of Glucose in New Choroidal Cerebrospinal Fluid of the Rabbit. Nature 215, 884–885 (1967). https://doi.org/10.1038/215884a0
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DOI: https://doi.org/10.1038/215884a0
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