Abstract
Baume, Nicholls and Baxter report the potent effect of lipopolysaccharide on gastric secretion as if this were a new observation1. But the effect was clearly described in 1950 (ref. 2). We have made similar experiments in conscious dogs with vagally denervated pouches of the body of the stomach. Gastric secretion was stimulated by a low dose of histamine given by constant intravenous infusion (100 µg/h of histamine base). Gastric acid secretion was abolished by doses of 10 µg/kg of Pseudo-monas polysaccharide pyrogen (‘Piromen’, Flint Laboratories Inc.) given intravenously over a period of about 20 min during stimulation with histamine. Secretion failed progressively over 2–3 h during which time the dogs developed pyrexia as indicated by a thermistor in the rectum (Fig. 1). In control experiments in which saline was given in place of ‘Piromen’ secretion was maintained.
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References
Baume, P. E., Nicholls, A., and Baxter, C. H., Nature, 215, 59 (1967).
Blickenstaff, D., and Grossman, M. I., Amer. J. Physiol., 160, 567 (1950).
Wyllie, J. H., Limbosch, J.-M., and Nyhus, L. M., Scand. J. Gastroenterol. (in the press).
Mignon, M., Limbosch, J.-M., Wyllie, J. H., Rheault, M. J., and Nyhus, L. M., Scand. J. Gastroenterol., 1, 124 (1966).
Cooper, K. E., Fed. Proc., 22, 721 (1963).
Brodie, D. A., and Kundrats, S., Gastroenterology, 47, 171 (1964).
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WYLLIE, J., LIMBOSCH, JM. & NYHUS, L. Inhibition of Gastric Acid Secretion by Bacterial Lipopolysaccharide. Nature 215, 879 (1967). https://doi.org/10.1038/215879a0
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DOI: https://doi.org/10.1038/215879a0
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