Abstract
THE immunological response of adult rabbits to bovine serum albumin (BSA) can usually be completely suppressed by an intravenous injection of 10 mg of centrifuged bovine albumin (CBA), but this unresponsive state can in turn be prevented by the injection of a heat-killed suspension of Corynebacterium parvum at the same time or 6 days in advance1. C. parvum also augments the production in the adult rabbit of anti-BSA antibody to either CBA or partially aggregated BSA, and at the same time enhances the relative binding affinity of the antibody2,3. We have now been able to show that in neonatal as distinct from adult rabbits C. parvum does not impede the induction of immunological unresponsiveness to BSA, and that in adult rabbits a suspension of the organism is ineffective as a means of abrogating a state of unresponsiveness already established.
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PINCKARD, R., WEIR, D. & McBRIDE, W. Effects of Corynebacterium parvum on Immunological Unresponsiveness to Bovine Serum Albumin in the Rabbit. Nature 215, 870–871 (1967). https://doi.org/10.1038/215870a0
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DOI: https://doi.org/10.1038/215870a0
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