Abstract
DURING a long-term study of the effect of age at exposure on the incidence of leukaemia after whole-body irradiation, the age dependence of cell killing of the haemopoietic cells of the mouse was investigated. The variation of radiosensitivity with age has been described previously1, using as an end-point the LD50/30 days mortality, and might reflect a variation of the radiosensitivity of haemopoietic cells, because death after midlethal doses of radiation is caused mainly by their injury. To test the radio-sensitivity of these cells and its dependence on age the following investigation was carried out.
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References
Lindop, P. J., and Rotblat, J., Brit. J. Radiol., 35, 23 (1962).
McCulloch, E. A., and Till, J. E., Radiat. Res., 13, 115 (1961).
Till, J. E., and McCulloch, E. A., Radiat. Res., 18, 96 (1963).
Lindop, P. J., and Musgrove, J., Phys. Med. Biol., 8, 325 (1963).
McCulloch, E. A., and Till, J. E., J. Cell. Comp. Physiol., 61, 308 (1963).
Becker, A. J., McCulloch, E. A., and Till, J. E., Nature, 197, 452 (1963).
Lajtha, L. G., in Current Topics in Radiation Research, 1 (edit. by Ebert, M., and Howard, A.), 139 (N. Holland Publishing Co., Amsterdam, 1965).
Whitmore, G. F., and Till, J. E., in Annual Review of Nuclear Science, 14, 347 (Annual Reviews Inc., Palo Alto, California. 1964).
Silini, G., and Pozzi, L. V., Min. Radiol. Fisiot. e Radiobiol., 10, 332 (1965).
Simonovitch, L., Till, J. E., and McCulloch, E. A., Radiat. Res., 24, 482 (1965).
Becker, A. J., McCulloch, E. A., Siminovitch, L., and Till, J. E., Blood, 26, 296 (1965).
Lindop, P. J., and Rotblat, J., Nature, 208, 1070 (1965).
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PROUKAKIS, C., LINDOP, P. Age Dependence of Radiation Sensitivity of Haemopoietic Cells in the Mouse. Nature 215, 655–656 (1967). https://doi.org/10.1038/215655a0
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DOI: https://doi.org/10.1038/215655a0
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