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Age Dependence of Radiation Sensitivity of Haemopoietic Cells in the Mouse

Abstract

DURING a long-term study of the effect of age at exposure on the incidence of leukaemia after whole-body irradiation, the age dependence of cell killing of the haemopoietic cells of the mouse was investigated. The variation of radiosensitivity with age has been described previously1, using as an end-point the LD50/30 days mortality, and might reflect a variation of the radiosensitivity of haemopoietic cells, because death after midlethal doses of radiation is caused mainly by their injury. To test the radio-sensitivity of these cells and its dependence on age the following investigation was carried out.

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References

  1. Lindop, P. J., and Rotblat, J., Brit. J. Radiol., 35, 23 (1962).

    Article  CAS  Google Scholar 

  2. McCulloch, E. A., and Till, J. E., Radiat. Res., 13, 115 (1961).

    Article  ADS  Google Scholar 

  3. Till, J. E., and McCulloch, E. A., Radiat. Res., 18, 96 (1963).

    Article  ADS  CAS  Google Scholar 

  4. Lindop, P. J., and Musgrove, J., Phys. Med. Biol., 8, 325 (1963).

    Article  CAS  Google Scholar 

  5. McCulloch, E. A., and Till, J. E., J. Cell. Comp. Physiol., 61, 308 (1963).

    Article  Google Scholar 

  6. Becker, A. J., McCulloch, E. A., and Till, J. E., Nature, 197, 452 (1963).

    Article  ADS  CAS  Google Scholar 

  7. Lajtha, L. G., in Current Topics in Radiation Research, 1 (edit. by Ebert, M., and Howard, A.), 139 (N. Holland Publishing Co., Amsterdam, 1965).

    Google Scholar 

  8. Whitmore, G. F., and Till, J. E., in Annual Review of Nuclear Science, 14, 347 (Annual Reviews Inc., Palo Alto, California. 1964).

    Google Scholar 

  9. Silini, G., and Pozzi, L. V., Min. Radiol. Fisiot. e Radiobiol., 10, 332 (1965).

    CAS  Google Scholar 

  10. Simonovitch, L., Till, J. E., and McCulloch, E. A., Radiat. Res., 24, 482 (1965).

    Article  ADS  Google Scholar 

  11. Becker, A. J., McCulloch, E. A., Siminovitch, L., and Till, J. E., Blood, 26, 296 (1965).

    CAS  PubMed  Google Scholar 

  12. Lindop, P. J., and Rotblat, J., Nature, 208, 1070 (1965).

    Article  ADS  CAS  Google Scholar 

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PROUKAKIS, C., LINDOP, P. Age Dependence of Radiation Sensitivity of Haemopoietic Cells in the Mouse. Nature 215, 655–656 (1967). https://doi.org/10.1038/215655a0

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