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Effect of Antilymphocytic Antibody and Antibody Fragments on Human Lymphocytes in vitro

Nature volume 215, pages 591–594 (1967)Cite this article

Abstract

The mode of action of horse anti-lymphocyte serum (IgG) and its pepsin fragments has been investigated by lymphocyte agglutination tests, cytotoxic tests and the uptake of uridine and thymidine. It is found that its divalent pepsin fragment (F(ab′)2) agglutinates lymphocytes and stimulates the uptake of uridine and thymidine whereas the univalent fragment (Fab′) is inactive in all these tests.

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Authors and Affiliations

  1. Department of Surgical Science, University of Edinburgh and MRC Research Group on Clinical and Experimental Problems of Transplantation, University of Edinburgh,

    M. F. A. WOODRUFF, B. REID & K. JAMES

Authors
  1. M. F. A. WOODRUFF
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  2. B. REID
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  3. K. JAMES
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WOODRUFF, M., REID, B. & JAMES, K. Effect of Antilymphocytic Antibody and Antibody Fragments on Human Lymphocytes in vitro. Nature 215, 591–594 (1967). https://doi.org/10.1038/215591a0

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