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Time Sequence of DNA Replication in Heteropycnotic X

Nature volume 215, pages 535–536 (1967)Cite this article

Abstract

RESULTS obtained with different techniques suggest that heteropycnotic X, that is, the late-replicating X, in human female cells is not completely inactivated1–5. If the chromatin which is not late-replicating can be genetically active, then the observation of bands with little or no labelling by tritiated thymidine in the terminal phase of the S period may also indicate the presence of non-inactivated X linked genes on heteropycnotic X. By means of autoradiographic techniques6, non-late-replicating regions have been shown on this chromosome, but the validity of this observation is questioned by the finding, in the same experiment, of X chromosomes intensely labelled over their whole length7.

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Authors and Affiliations

  1. Medical Clinic of Turin Medical School, Turin

    F. GAVOSTO, L. PEGORARO, G. ROVERA & P. MASERA

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  1. F. GAVOSTO
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  2. L. PEGORARO
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  3. G. ROVERA
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  4. P. MASERA
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GAVOSTO, F., PEGORARO, L., ROVERA, G. et al. Time Sequence of DNA Replication in Heteropycnotic X. Nature 215, 535–536 (1967). https://doi.org/10.1038/215535b0

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