Abstract
DEAE ‘Sephadex A-25’ has oral hypocholesterolaemic activity in cockerels and dogs1. This material is thought to interrupt the enterohepatic circulation of bile acids by binding them in the intestinal lumen and enhancing their excretion in the faeces. DEAE ‘Sephadex A-25’ is a cross-linked tertiary amine derivative of dextran with an average molecular weight of 25,000 and is insoluble in water and salt solutions. As such it would not be expected to be absorbed intact from the gastrointestinal tract. The possibility that the polymer might be hydrolysed by intestinal enzymes and the hydrolysis products absorbed has not, however, heretofore been investigated.
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PARKINSON, T. Metabolism of Orally Administered Dextran and ‘Sephadex’ Derivatives in the Rat. Nature 215, 415–416 (1967). https://doi.org/10.1038/215415a0
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DOI: https://doi.org/10.1038/215415a0
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