Abstract
TETRODOTOXIN and saxitoxin are neurotoxins with very similar biological actions, though they are chemically distinct. Tetrodotoxin reduces the amplitude of the end plate potential elicited by neural stimulation. At the same time, however, the end plate membrane remains entirely responsive to acetylcholine1–3. Kao and Nishiyama4 found that the actions of saxitoxin on the neuromuscular system are similar to those of tetrodotoxin. The blockade of neuromuscular transmission by saxitoxin affects the motor axon and muscle membrane, while the end plate receptor is not affected.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Elmquist, D., and Feldman, D. S., Acta Physiol. Scand., 64, 475 (1965).
Furukawa, T., Sasaoka, T., and Hosoya, Y., Jap. J. Physiol., 9, 143 (1959).
Katz, B., Twenty-third Intern. Cong. Physiol. Sci. (1965).
Kao, C. Y., and Nishiyama, A., J. Physiol., 180, 50 (1965).
Ozeki, M., Freeman, A. R., and Grundfest, H., J. Gen. Physiol., 49, 1915 (1966).
Kao, C. Y., Pharmacol. Rev., 18, 998 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
NISHIYAMA, A. Effect of Saxitoxin on the End Plate of Frog Muscle. Nature 215, 201–202 (1967). https://doi.org/10.1038/215201a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/215201a0
This article is cited by
-
Dehydration-Rehydration Vesicles: A Simple Method for High Yield Drug Entrapment in Liposomes
Nature Biotechnology (1984)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
