Abstract
ELECTRON microscopy showed a virus in the tissues of a strain of guinea-pigs in which leukaemia arose spontaneously. This strain of guinea-pigs dates back to 1906 when inbreeding began at the Bureau of Animal Industry of the US Department of Agriculture1. We are at present using one of these families, now known as strain No. 2, in our research. In 1940, these animals were transferred to the National Cancer Institute where inbreeding of thib strain has continued until now. A high degree of genetic homogenicity has resulted from this method of breeding. In 1954, Congdon and Lorenz reported several forms of acute lymphatic leukaemia2. Ten transplantable tumours were found, and of these four were carried and three were subsequently lost.
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Heston, W. E., and Deringer, M. K., J. Nat. Cancer Inst., 13, 705 (1952).
Congdon, C. C., and Lorenz, E., Amer. J. Pathol., 30, 337 (1954).
Opler, S. R., Sixth Intern. Cong. I.A.P., Kyoto, October (1967).
Opler, S. R., Sci. Proc. Amer. Assoc. Pathol. and Bact., March (1967).
Opler, S. R., Proc. Amer. Assoc. Cancer Res., March (1967).
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OPLER, S. Animal Model of Viral Oncogenesis. Nature 215, 184 (1967). https://doi.org/10.1038/215184a0
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DOI: https://doi.org/10.1038/215184a0
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