Abstract
CHANCE1 applied the crossover theorem to a study of intact yeast cells, and reported an apparent crossover point (or phosphorylation site) between pyridine nucleotide and flavoprotein (site I), between cytochromes b and c (site II) and between eytochrome c and cytochrome oxidase (site III). These observations led to the expectation that intact isolated yeast mitochondria would exhibit no anomalies with respect to their phosphorylation capacity. More recently Mattoon and Sherman2 used loosely coupled yeast mitochondria and obtained indirect results supporting the observations of Chance.
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References
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BALCAVAGE, W., MATTOON, J. Effect of Rotenone on the Alcohol Dehydrogenase of Yeast Mitochondria. Nature 215, 166–168 (1967). https://doi.org/10.1038/215166a0
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DOI: https://doi.org/10.1038/215166a0
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