Abstract
AN enzyme or enzyme system which can degrade calf skin collagen soluble in acid at an acid pH is present in the lysosomes of rat liver cells1–4. It has also been shown5–8that there is a collagenolytie enzyme system in homogenates of rat bone, and that this system, which can convert rat bone collagen to a soluble form, is localized in sub-cellular particles with some of the properties of lysosomes6,7. Experiments with radioactively labelled rat bone collagen8 suggested that this material is not made appreciably soluble by treatment with large granule fractions from homogenates of kidney, brain, leucocytes and liver at pH 7.4. In this report, the effect of rat liver lysosomes on various insoluble collagens at a variety of pH values is described.
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WYNN, C. Solubilization of Insoluble Collagens by Rat Liver Lysosomes. Nature 215, 1191–1192 (1967). https://doi.org/10.1038/2151191a0
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DOI: https://doi.org/10.1038/2151191a0
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