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Role of Carbon Dioxide in Erythropoiesis

Nature volume 215, pages 1166–1167 (1967)Cite this article

Abstract

THE use of gas mixtures containing 5 per cent carbon dioxide gas has become a standard procedure for the cultivation of cells in vitro. In some systems, however, a higher concentration has proved essential1,2. In bone marrow cultures different concentrations of carbon dioxide have been used3,4, but the interest has centred on the role of oxygen and little attention has been paid to the function of the other gases in the mixtures. In the present system for the cultivation of rat bone marrow in vitro 30 per cent carbon dioxide (which is considerably higher than any concentration, previously reported) has been found to stimulate erythropoiesis5. This effect has now been investigated in detail.

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Authors and Affiliations

  1. Division of Radiation Biology, National Research Council of Canada, Ottawa

    HELEN J. MORTON

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  1. HELEN J. MORTON
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MORTON, H. Role of Carbon Dioxide in Erythropoiesis. Nature 215, 1166–1167 (1967). https://doi.org/10.1038/2151166a0

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