Abstract
THERE is some evidence that histones inhibit synthesis of DNA-dependent RNAs and thereby regulate genetic activity1–3. If this is so they should influence embryonic development by interfering with the differential expression of genetic activity. The effects of calf thymus histone fractions on the development of the chick embryos seem to depend on the stage chosen for treatment while those of poly-L-lysine do not4,5. Such effects are presumably caused by histones complexing with cytoplasmic molecules such as those concerned in embryonic inductions which appear in a sequential order during development6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Huang, R. C., and Bonner, J., Proc. US Nat. Acad. Sci., 48, 1216 (1962).
Barr, G. C., and Butler, J. A. V., Nature, 199, 1170 (1963).
Allfrey, V. G., Littau, V. G., and Mirsky, A. E., Proc. US Nat. Acad. Sci., 49, 414 (1963).
Sherbet, G. V., J. Embryol. Exp. Morph., 16, 159 (1966).
Sherbet, G. V., in Histones, Their Role in the Transfer of Genetic Information Ciba Found. Study Group, 24 (J. & A. Churchill, 1966).
Sherbet, G. V., Prog. Biophys. Mol. Biol., 16, 89 (1966).
Waddington, C. H., Phil. Trans. Roy. Soc., B, 221, 179 (1932).
Sherbet, G. V., J. Embryol. Exp. Morph., 11, 227 (1963).
Sherbet, G. V., and Mulherkar, L., Roux. Arch. Entwickl.-Mech., 155, 701 (1965).
Sherbet, G. V., Naturwissenschaften, 20, 471 (1962).
Lakshmi, M. S., and Sherbet, G. V., Naturwissenschaften, 40, 501 (1962).
Sherbet, G. V., and Lakshmi, M. S., Experientia (in the press).
Sherbet, G. V., and Mulherkar, L., Roux. Arch. Entwickl.-Mech., 154, 506 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SHERBET, G., LAKSHMI, M. Loss of Neural Inductive Capacity of the Chick Primary Organizer by Treatment with Histone and its Restoration by Follicle-stimulating Hormone. Nature 215, 1089–1090 (1967). https://doi.org/10.1038/2151089a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2151089a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.