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Cellular Basis of the Immunological Defects in Thymectomized Mice

Abstract

The thymus is known to play a central part in the establishment of immunological competence. The following three articles describe experiments aimed at defining the nature of the cellular basis for the immunological deficiency of neonatally thymectomized mice.

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References

  1. Gowans, J. L., and Knight, E. J., Proc. Roy. Soc., B, 159, 257 (1964). Marchesi, V. T., and Gowans, J. L., Proc. Roy. Soc., B, 159, 283 (1964).

    ADS  CAS  Google Scholar 

  2. Gowans, J. L., McGregor, D. D., Cowen, D. M., and Ford, C. E., Nature, 196, 651 (1962).

    Article  ADS  CAS  Google Scholar 

  3. Gowans, J. L., Ann. N.Y. Acad. Sci., 99, 432 (1962).

    Article  ADS  CAS  Google Scholar 

  4. Miller, J. F. A. P., Lancet, ii, 748 (1961); Proc. Roy. Soc., B, 156, 415 (1962). Good, R. A., Dalmasso, A. P., Martinez, C., Archer, O. K., Pierce, J. C., and Papermaster, B. W., J. Exp. Med., 116, 773 (1962); Janković, B. D., Waksman, B. H., and Arnason, B. G., ibid., 116, 159 (1962); Waksman, B. H., Arnason, B. G., and Jankovič, B. D., ibid., 116, 187 (1962); Parrott, D. M., de Sousa, M. A. B., and East, J., ibid., 123, 191 (1966).

    Article  Google Scholar 

  5. Friedman, H., Proc. Soc. Exp. Biol. and Med., 118, 1176 (1965). Miller, J. F. A. P., de Burgh, P. M., and Grant, G. A., Nature, 208, 1332 (1965).

    Article  CAS  Google Scholar 

  6. Miller, J. F. A. P., Brit. J. Cancer, 14, 93 (1960).

    Article  CAS  Google Scholar 

  7. Boak, J. L., and Woodruff, M. F. A., Nature, 205, 396 (1965).

    Article  ADS  CAS  Google Scholar 

  8. McIntire, K. R., Sell, S., and Miller, J. F. A. P., Nature, 204, 151 (1964).

    Article  ADS  CAS  Google Scholar 

  9. Shrewsbury, M. M., Proc. Soc. Exp. Biol. and Med., 101, 492 (1959). Gesner, B. M., and Gowans, J. L., Brit. J. Exp. Path., 43, 424 (1962).

    Article  CAS  Google Scholar 

  10. Clark, W. G. B., Williams, C. B., and Yoffey, J. M., J. Lab. Clin. Med., 67, 439 (1966).

    CAS  PubMed  Google Scholar 

  11. Bierring, F., Ciba Found. Symp.: Haemopoiesis: Cell Production and its Regulation (edit. by Wolstenholme, G. E. W., and O'Connor, M.), 185 (Churchill, London, 1960).

    Google Scholar 

  12. Schooley, M. C., and Kelly, L. S., in The Thymus in Immunobiology (edit. by Good, R. A., and Gabrielsen, A. E.), 236 (Hoeber-Harper, New York, 1964).

    Google Scholar 

  13. Rieke, W. O., Anat. Rec., 148, 327 (1964).

    Google Scholar 

  14. McGregor, D. D., and Gowans, J. L., J. Exp. Med., 117, 303 (1963).

    Article  CAS  Google Scholar 

  15. Miller, J. F. A. P., Brit. Med. Bull., 21, 111 (1965).

    Article  CAS  Google Scholar 

  16. Simonsen, M., Prog. Allergy, 6, 349 (1962).

    CAS  PubMed  Google Scholar 

  17. Rieke, W. O., Science, 152, 535 (1966).

    Article  ADS  CAS  Google Scholar 

  18. Kennedy, J. C., Till, J. E., Siminovitch, L., and McCulloch, E. A., J. Immunol., 96, 973 (1966).

    CAS  PubMed  Google Scholar 

  19. Ford, W. L., Gowans, J. L., and McCullagh, P. J., Ciba Found. Symp.: The Thymus: Experimental and Clinical Aspects (edit. by Wolstenholme, G. E. W., and Porter, R.), 58 (Churchill, London, 1966).

    Google Scholar 

  20. Osoba, D., and Miller, J. F. A. P., Nature, 199, 653 (1963). Law, L. W., Trainin, N., Levey, R. H., and Barth, W. F., Science, 143, 1049 (1964).

    Article  ADS  CAS  Google Scholar 

  21. Metcalf, D., J. Cell. Physiol., 67, Suppl., i, 149 (1966).

    Article  Google Scholar 

  22. Miller, J. F. A. P., Science, 144, 1544 (1964); Brit. Med. Bull., 21, 111 (1965).

    Article  ADS  CAS  Google Scholar 

  23. Jerne, N. K., Nordin, A. A., and Henry, C., Cell Bound Antibodies, 109 (Wistar Institute Press, Philadelphia, 1963).

    Google Scholar 

  24. Miller, J. F. A. P., de Burgh, P. M., and Grant, G., Nature, 203, 1332 (1966).

    Google Scholar 

  25. Sinclair, N. R., Nature, 208, 1104 (1965).

    Article  ADS  CAS  Google Scholar 

  26. Rogister, G., Transplantation, 3, 669 (1965). Dukor, P., Dietrich, F. M., and Rosenthal, M., Clin. Exp. Immunol., i, 389 (1966); Sinclair, N. R., and Millican, D., ibid. (in the press).

    Article  CAS  Google Scholar 

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MILLER, J., MITCHELL, G. & WEISS, N. Cellular Basis of the Immunological Defects in Thymectomized Mice. Nature 214, 992–997 (1967). https://doi.org/10.1038/214992a0

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