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Mast Cell Proliferation in Adult Mice

Nature volume 214, pages 930–931 (1967)Cite this article

Abstract

ANIMALS given injections of tritiated thymidine to label deoxyribonucleic acid (DNA) have shown a very small percentage of labelled mast cells when killed after intervals of 0.5 h to 21 days1–5, and Allen6 has suggested that in rats aged 10–120 days proliferation of mast cells is inversely related to age. Single injections of tritiated thymidine indicate the proportion of cells synthesizing DNA, but continuous infusion of the labelled thymidine provides direct information about cell turnover, and results are presented here of the first application of this technique to the investigation of mast cells.

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Authors and Affiliations

  1. Department of Pathology, St. Mary's Hospital Medical School, London, W.2.

    W. K. BLENKINSOPP

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  1. W. K. BLENKINSOPP
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BLENKINSOPP, W. Mast Cell Proliferation in Adult Mice. Nature 214, 930–931 (1967). https://doi.org/10.1038/214930a0

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