Abstract
OPTIMAL conversion of prothrombin to thrombin requires the presence of at least four factors, namely, factor V (pro-accelerin, Ac-globulin), factor X (Stuart-Prower factor) in an activated form (Xa), phospholipids and calcium ions. It has been demonstrated that these species can react together to form a macromolecular complex which has prothrombinase activity1. In this communication prothrombinase is defined as the enzymatic activity which produces a conversion of prothrombin to thrombin.
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BARTON, P., JACKSON, C. & HANAHAN, D. Relationship between Factor V and Activated Factor X in the Generation of Prothrombinase. Nature 214, 923–924 (1967). https://doi.org/10.1038/214923a0
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DOI: https://doi.org/10.1038/214923a0
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