Abstract
HAPLOIDIZATION, mitotic crossing-over and mitotic nondisjunction are three modalities of mitotic recombination which could permit the mapping of human genes via genetic analysis of cultured human somatic cells1. It is assumed2, but not proved, that at least one of these mechanisms, mitotic nondisjunction, is of routine occurrence in established cultures of diploid or essentially diploid human somatic cells. We report here cytogenetic evidence for the repeated occurrence of this process within clones of fibroblasts derived from the skin of a child with Down's syndrome (mongolism). In this presumably exceptional genotype, the event involved only acrocentrics; with one exception, these were all small (G group)3 acrocentric chromosomes.
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MARTIN, G., SPRAGUE, C. & BRYANT, J. Mitotic Nondisjunction in Cultivated Human Cells. Nature 214, 612–613 (1967). https://doi.org/10.1038/214612a0
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DOI: https://doi.org/10.1038/214612a0
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