Abstract
THE immunogenicity of interferon has been demonstrated by a few workers1–4. Paucker4 prepared immune sera in rabbits and guinea-pigs against interferon produced in vitro by Newcastle disease virus (NDV) in L mouse fibroblasts and by WSE strain of influenza A virus in embryonated eggs. L cell interferon antisera did not neutralize chick embryo interferon, and chick interferon antisera did not neutralize L cell interferon. For this study, the cells producing interferon belonged to two different animal species. Because interferon is a cell protein, it could be expected that interferon antisera would be specific of the animal species which had produced this interferon and that, furthermore, neutralizing antibodies might be detected only in the cell species that had produced interferon. This was demonstrated by Paucker4.
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References
Nagano, Y., and Kojima, Y., C.R. Soc. Biol. (Paris), 154, 2172 (1960).
Nagano, Y., and Kojima, Y., C.R. Soc. Biol. (Paris), 155, 1183 (1961).
Paucker, K., and Kantell, K., Virology, 18, 145 (1962).
Paucker, K., J. Immunol., 94, 371 (1964).
Lampson, G. P., Tyttel, R. A., Nemes, M., and Hilleman, M. R., Proc. Soc. Exp. Biol. and Med., 112, 248 (1963).
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FAUCONNIER, B. Antigenic Identity of Interferons induced by Different Viruses in the same Cell System. Nature 214, 591–592 (1967). https://doi.org/10.1038/214591a0
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DOI: https://doi.org/10.1038/214591a0
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