Abstract
Extracts of vertebrate epidermis contain an antimitotic chemical messenger, called the epidermal chalone, which appears to be of central importance in the control of epidermal mitosis. Other similar chalones have been reported in other tissues. The epidermal chalone is tissue-specific, but it is now shown to be neither species- nor class-specific. This indicates that the epidermal mitotic control mechanisms must be closely similar in all vertebrates from fishes to mammals.
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BULLOUGH, W., LAURENCE, E., IVERSEN, O. et al. The Vertebrate Epidermal Chalone. Nature 214, 578–580 (1967). https://doi.org/10.1038/214578a0
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DOI: https://doi.org/10.1038/214578a0
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