Antilipoprotein Nuoro Serum (C.P.) and its Relation to Sera C. de B. and L.L.

Abstract

SINCE the original observation by Marie¹ that sera from poly-transfused subjects can cause precipitate formation with some but not all human sera, several isoprecipitin sera with various specificities have been discovered. The first reagent to be more closely investigated was serum C. de B. found by Allison and Blumberg². This antiserum was originally denoted anti-Ag (a+) and sera reacting positively with this serum were regarded as being Ag (a +). One of us (J.H.), however, showed that serum C. de B. is a mixture of at least three physically separable antibodies³ and the notation anti-a₁ anti-x and anti-z was adopted for these three antibodies^3,4. Thus sera which previously had been regarded as Ag (a +) could be any of seven different combinations of the three antigens a₁, x and z.