Abstract
PHYTOHAEMAGGLUTININ is known to stimulate the human peripheral blood lymphocytes to enlarge and divide1. The process of the morphological transformation2 of these cells through nucleolated prolymphocytes into blastoid cells is accompanied by cytochemical3 changes and the acquisition of the ability to synthesize RNA and DNA4–6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Nowell, P. C., Cancer Res., 20, 426 (1960).
Yoffey, J., Winter, G., Osmond, D., and Meek, E., Brit. J. Haematol., 11, 488 (1965).
Quaglino, D., Hayhoe, F. G. J., and Flemans, R. J., Nature, 196, 338 (1962).
Bender, M. A., and Prescott, D. M., Exp. Cell Res., 27, 221 (1962).
Darżynkiewicz, Z., Krassowski, T., and Skopińiska, E., Nature, 207, 1402 (1965).
Cooper, H., and Rubin, A., Blood, 25, 1014 (1965).
Barer, R., and Josephs, S., Quart. J. Micros. Sci., 95, 271 (1954).
Terasaki, P. I., Cannon, J. A., and Longmire, W. P., Proc. Soc. Exp. Biol. N. Y., 102, 280 (1959).
Ostrowski, K., Darżynkiewicz, Z., Sawicki, W., and Stocka, Z., Folia Histochem. Cytochem., 1, 553 (1963).
Ostrowski, K., Darżynkiewicz, Z., Sawicki, W., and Stocka, Z., Acta Biochim. Polon., 11, 99 (1964).
Darżynkiewicz, Z., and Wieckowski, J., Folia Histochem. Cytochem., 3, 275 (1965).
Davies, H. G., Williams, M. H. F., Chayen, J., and La Cour, L. F., Quart. J. Micros. Sci., 95, 271 (1954).
Ottoson, R., Khan, K., and Glick, D., Exp. Cell Res., 14, 567 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DARŻYNKIEWICZ, Z., DOKOV, V. & PIEŃKOWSKI, M. Dry Mass of Lymphocytes during Transformation after Stimulation by Phytohaemagglutinin. Nature 214, 1265–1266 (1967). https://doi.org/10.1038/2141265a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2141265a0
This article is cited by
-
Is protein synthesis necessary for the commitment of lymphocyte transformation?
Nature (1978)
-
Morphometric study of normal and phytohemagglutinin-stimulated lymphocytes
Zeitschrift für Zellforschung und mikroskopische Anatomie (1972)
-
Effect of penicillin on ribonucleic acid synthesis in lymphocytes of sensitized individuals
Experientia (1967)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.