Abstract
VARIANTS of human adenylate kinase (AK) ATP : AMP phosphotransferase (E.C.2.7.4.3) have been characterized on horizontal starch-gel electrophoresis by Fildes and Harris1. Three autosomally inherited isozyme forms were named AK 1, AK 2–1, and AK 2. The heterozygous form, AK 2–1, occurred in approximately 10 per cent of a British population. This communication describes a vertical starch-gel electrophoretic technique for AK; substantiates the genetics of AK 1, AK 2–1 and AK 2; characterizes a previously undescribed variant of AK; reports on AK in populations of Caucasians of European origin, Negroes of the United States, West Africans and Lacandón Mayans; and introduces some biochemical properties of the enzyme.
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BOWMAN, J., FRISCHER, H., AJMAR, F. et al. Population, Family and Biochemical Investigation of Human Adenylate Kinase Polymorphism. Nature 214, 1156–1158 (1967). https://doi.org/10.1038/2141156a0
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DOI: https://doi.org/10.1038/2141156a0
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