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Antilymphocyte Serum and Staphylococcal Infection

Nature volume 214, pages 1138–1139 (1967)Cite this article

Abstract

HETEROLOGOUS anti-lymphocyte serum can produce a marked lymphopenia in a number of animal species, and has been shown to be a potent immunosuppressive agent as judged by the prolongation of skin graft survival in the mouse and rat1,2, and suppression of delayed hypersensitivity reactions in the guinea-pig3. Because of this ability to produce a selective lymphopenia, we have investigated the development of acute bacterial inflammatory lesions in the guinea-pig in the presence of a lymphopenia resulting from treatment with anti-lymphocyte serum. We hoped that work would provide information about the role of the lymphocyte in acute bacterial inflammation, as well as indicating the possible effects of clinical use of such a serum in organ transplantation on the host's defence mechanisms against bacterial infection.

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References

  1. Monaco, A. P., Wood, M. L., Gray, J. G., and Russell, P. S., J. Immunol., 96, 217 (1966).

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Author notes

  1. PETER J. MORRIS

    Present address: Department of Surgery, Melbourne University, Melbourne, Australia

Authors and Affiliations

  1. Department of Surgery, Harvard Medical School, General Surgical Services, Massachusetts General Hospital, Boston, Massachusetts

    PETER J. MORRIS & JOHN F. BURKE

Authors
  1. PETER J. MORRIS
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  2. JOHN F. BURKE
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MORRIS, P., BURKE, J. Antilymphocyte Serum and Staphylococcal Infection. Nature 214, 1138–1139 (1967). https://doi.org/10.1038/2141138a0

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