Abstract
IT is well established in rats that the increased vascular permeability which follows the intrapleural injection of turpentine is due to the local release of histamine and is continued by the activation of other mechanisms1,2. Our experiments on sheep have shown a similar pattern of immediate histamine release and later continuation of the increased vascular permeability. Following the report by Judah, Ahmed and McLean3 of the similarity of action between the antihistamine promethazine and the cardiac glycoside strophanthin G, strophanthin G was used as a possible suppressor of the early inflammatory changes in the sheep.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Spector, W. G., and Willoughby, D. A., J. Path. Bact., 77, 1 (1959).
Hurley, J. V., and Spector, W. G., J. Path. Bact., 89, 245 (1965).
Judah, J. D., Ahmed, K., and McLean, A. E. M., J. Path. Bact., 89, 619 (1965).
Halpern, B. N., Cruchaud, S., Vermeil, G., and Roux, J. L., Arch. Intern. Pharmacodyn., 82, 425 (1950).
Spector, W. G., and Willoughby, D. A., J. Path. Bact., 73, 133 (1957).
Parratt, J. R., and West, G. B., J. Physiol., 140, 105 (1958).
Parratt, J. R., and West, G. B., Brit. J. Pharmacol., 13, 65 (1958).
Wilson, C. O., and Gisvold, O., Text Book of Organic Medicinal and Pharmaceutical Chemistry, 536 (1962).
Lewis, J. J., An Introduction to Pharmacology, 243 (1964).
Gallagher, C. H., Gupta, D. N., Judah, J. D., and Rees, K. R., J. Path. Bact., 72, 193 (1956).
Judah, J. D., Ahmed, K., and McLean, A. E. M., in Cellular Injury, 187 (edit. by de Reuck, A. V. S., and Knight, Julie) (Ciba Foundation Symposium, London, 1964).
Rees, K. R., Sinha, K. P., and Spector, W. G., J. Path. Bact., 81, 107 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LANCASTER, M., VEGAD, J. Suppression of the Early Inflammatory Response in the Sheep by Strophanthin G. Nature 213, 840–841 (1967). https://doi.org/10.1038/213840b0
Issue Date:
DOI: https://doi.org/10.1038/213840b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
