Abstract
MANY substances are released in anaphylaxis, including histamine1, bradykinin2,3 and slow-reacting substance3–5. In some species, histamine6, bradykinin7–10 and possibly slow-reacting substance11 liberate catecholamines into the circulation, and so the anaphylactic reaction may also be expected to lead to catecholamine release, and some evidence suggests that it does3. This communication demonstrates directly that, in the guinea-pig, histamine, bradykinin, slow-reacting substance and anaphylaxis all liberate catecholamines into the circulation; their relative effects are estimated and their roles discussed.
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PIPER, P., COLLIER, H. & VANE, J. Release of Catecholamines in the Guinea-pig by Substances involved in Anaphylaxis. Nature 213, 838–840 (1967). https://doi.org/10.1038/213838a0
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DOI: https://doi.org/10.1038/213838a0
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