Abstract
THE recent demonstration of a pyridoxine phosphate oxidase in extracts of Escherichia coli1,2 and the accumulation of pyridoxine phosphate by a mutant of this organism blocked in this step3 suggests that this oxidation is the ultimate step (A) in the biosynthesis of pyridoxal phosphate. If this is true, the kinase step (B) may be expected to have greater specificity for pyridoxine than for pyridoxal. This communication reports the testing of this hypothesis.
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KENNY, K., DEMPSEY, W. Phosphorylation of Pyridoxine by Escherichia coli B. Nature 213, 830 (1967). https://doi.org/10.1038/213830b0
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DOI: https://doi.org/10.1038/213830b0
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