Abstract
ADMINISTRATION of single, large doses of hydrocortisone causes a marked increase in synthesis of rat liver RNA and the activity of several enzymes1. A direct gene action and enhanced synthesis of specific messenger RNAs has been suggested2 and positive evidence for this hypothesis was presented3,4. In contrast, other experiments indicate that hydrocortisone provokes an unspecific stimulation of RNA synthesis5,6. In almost all the reported experiments, hydrocortisone was administered before injection of the labelled RNA precursors. In an attempt to elucidate the primary effects of hydrocortisone, we investigated the effects of administering this hormone after short term labelling of liver RNAs.
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References
Feigelson, P., Feigelson, M., and Greengard, O., Rec. Prog. Hormone Res., 18, 491 (1962).
Karlson, P., Persp. Biol. Med., 6, 203 (1963).
Lang, N., and Sekeris, C., Z. Physiol. Chem., 339, 238 (1964).
Barnabei, O., and Sereni, F., Biochim. Biophys. Acta, 91, 239 (1964).
Garren, L. D., Howell, R. R., and Tomkins, G. M., J. Mol. Biol., 9, 100 (1964).
Greenman, D., Wicks, W., and Kenney, F., J. Biol. Chem., 240, 4420 (1965).
Georgiev, G. P., and Mantieva, V. P., Biokhimia, 27, 949 (1962).
Tsanev, R. G., Markov, G. G., and Dessev, G. N., Biochem. J., 100, 204 (1966).
Tsanev, R. G., and Staynov, D. Z., Biokhimia, 29, 1126 (1964).
Katz, S., and Comb, D., J. Biol. Chem., 238, 3065 (1963).
Angelov, E., and Hadjiolov, A. A., Bull. Biochem. Res. Lab. Bulgarian Acad. Sci., 2, 77 (1964).
Sekeris, C., and Dukes, P. P., Second Meeting Fed. Europ. Biochem. Soc., Vienna, 1965, Abstr. A 131.
Dahmus, M., and Bonner, J., Proc. U.S. Nat. Acad. Sci., 54, 1370 (1966).
Hiatt, H. H., J. Mol. Biol., 5, 217 (1962).
Samarina, O., Lerman, M., Tumanian, V., Ananieva, L., and Georgiev, G. P., Biokhimia, 30, 880 (1965).
Perry, R. P., Nat. Cancer Inst. Monograph, 14, 73 (1964).
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VENKOV, P., ANGELOV, E., VALEVA, L. et al. Early Effects of Hydrocortisone on Rapidly Labelled Rat Liver Ribonucleic Acids. Nature 213, 807–809 (1967). https://doi.org/10.1038/213807a0
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DOI: https://doi.org/10.1038/213807a0
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