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Effect of Ionic Strength on the Apparent Anti-coagulant Activity of Bovine Heparin

Abstract

THE preparation of a series of fractions1 of commercial bovine heparin with varying molecular weight and biological activity by solvent (ethanol-water) elution and by Ecteola column chromatography gave us an opportunity to investigate the role of electrostatic interactions on the anti-coagulant activity of these fractions.

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LASKER, S., STIVALA, S. Effect of Ionic Strength on the Apparent Anti-coagulant Activity of Bovine Heparin. Nature 213, 804–805 (1967). https://doi.org/10.1038/213804a0

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