Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Viral Transformation of Monkey Kidney Cell Cultures

Abstract

Simian tumour virus SV40 induces transformation of primary cultures of cercopithecus monkey kidney cells. The cells become highly vacuolated, complement fixing viral antigen is formed and the cells become resistant to the cytopathic effects of the virus. It is probable that a persistent association develops between the cells and the virus genome.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Eddy, B. E., Fed. Proc., 21, 930 (1962).

    Google Scholar 

  2. Diderholm, H., and Wesslen, T., Arch. Ges. Virusfor., 17, 339 (1965).

    Article  CAS  Google Scholar 

  3. Rabson, A. S., Kirschstein, R. L., and Legallais, F. Y., J. Nat. Cancer Inst., 35, 981 (1965).

    CAS  PubMed  Google Scholar 

  4. Hsiung, C.-D., and Gaylord, jun., W. H., J. Exp. Med., 114, 975 (1961).

    Article  CAS  Google Scholar 

  5. Love, R., and Fernandes, M. V., J. Cell Biol., 25, 529 (1965).

    Article  CAS  Google Scholar 

  6. Fernandes, M., and Moorhead, P. S., Texas Rep. Biol. Med., 23, 242 (1965).

    Google Scholar 

  7. Moyer, A. W., Wallace, R., and Cox, H. R., J. Nat. Cancer Inst., 33, 227 (1964).

    CAS  PubMed  Google Scholar 

  8. Wallace, R., Proc. Soc. Exp. Biol. and Med., 116, 990 (1964).

    Article  CAS  Google Scholar 

  9. Hopps, H. E., Bernheim, B. C., Nisalak, A., and Smadel, J. E., Fed. Proc., 21, 454 (1962).

    Google Scholar 

  10. Huebner, R. J., Rowe, W. P., Turner, H. C., and Lane, W. T., Proc. U.S. Nat. Acad. Sci., 50, 379 (1963).

    Article  ADS  CAS  Google Scholar 

  11. Sabin, A. B., and Koch, M., Proc. U.S. Nat. Acad. Sci., 49, 304 (1963).

    Article  ADS  CAS  Google Scholar 

  12. Diderholm, H., Arch. Ges. Virusfor., 14, 39 (1963).

    Article  CAS  Google Scholar 

  13. Isaacs, A., in Perspectives in Virology (edit. by Pollard, M.), 2, 117 (Burgess Publishing Co., Minneapolis, 1962).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

WALLACE, R. Viral Transformation of Monkey Kidney Cell Cultures. Nature 213, 768–770 (1967). https://doi.org/10.1038/213768a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/213768a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing