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Mechanism of Action of Aminothiol Radioprotectors

Nature volume 213, pages 363–364 (1967)Cite this article

Abstract

How do aminothiols protect living cells from radiation ? One possibility is that they bind to and stabilize those parts of the DNA helix which are not covered by histones. This reduces both primary and secondary damage, and the DNA replication rate is decreased so that repair processes can act before alterations are replicated.

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Author notes

  1. P. E. BROWN

    Present address: Department of Organic Chemistry, University of Adelaide, Adelaide, South Australia

Authors and Affiliations

  1. Lawrence Radiation Laboratory, University of California, Berkeley, California

    P. E. BROWN

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  1. P. E. BROWN
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BROWN, P. Mechanism of Action of Aminothiol Radioprotectors. Nature 213, 363–364 (1967). https://doi.org/10.1038/213363a0

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