Abstract
THE classical reaction of the lung to the deposition of airborne silica is the formation of discrete nodules, which in man exhibit a characteristic disposition of dust and connective tissue fibres1,2. Although the experimental lesion does not reproduce all the human features3, I have confirmed that it remains focal and discrete4,5. In recent experiments on the disposal of inhaled particles within the lung parenchyma, specific pathogen-free (SPF) rats have been used in an attempt to eliminate the complication of pulmonary infection which not infrequently affects standard laboratory rats. The response of SPF rats differed greatly from that of the standard ones used in the earlier studies.
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HEPPLESTON, A. Atypical Reaction to Inhaled Silica. Nature 213, 199 (1967). https://doi.org/10.1038/213199a0
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DOI: https://doi.org/10.1038/213199a0
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