Abstract
CURRENT concepts of the mode of action of steroid hormones involve activation or inactivation of enzymes; alteration of the permeability of cellular or nuclear membranes; and activation or inactivation of the genome by gene derepression or repression1–3. More recent work with oestrogens appears to support the latter hypothesis. Among the reported biochemical effects, detectable only a few hours after hormone administration in vivo, are increased RNA (especially nuclear RNA) and protein biosynthesis, and increased activities of various enzymes, for example, RNA polymerase, enzymes which activate amino-acids and alkaline phosphatase4–6. These reactions occur relatively early, but they may be considered to be secondary to an undetected primary event.
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MAURER, H., ROUNDS, D. & RAIBORN, C. Effects of Oestradiol on Calf Endometrial Tissue in vitro. Nature 213, 182–183 (1967). https://doi.org/10.1038/213182a0
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DOI: https://doi.org/10.1038/213182a0
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