Abstract
THE unusual properties of the ε-group of Salmonella anatum phages to change the antigenic structure of the surface of their host bacterium first described by Uetake1,2 are also interesting from the point of view of their biological meaning. The results given by Uetake seem to justify this approach. Uetake found that a non-lysogenic strain of Salmonella anatum (A) with antigenic structure 3,10 and sensitive to the phage ε-15, when lysogenized by it, gives rise to a lysogenic strain A (ε-15) with antigenic structure changed from 3,10 to 3,15 and sensitive to the phage ε-34. When this new strain (with antigenic structure 3,15) is lysogenized by ε-34, the resulting strain, containing both prophages A (ε-15, ε-34), has again a new antigenic structure (3) (15) 34. When the original strain A (with antigenic structure 3,10) is lysogenized in special conditions by ε-34 only2, no antigenic change occurs. On the basis of a very detailed analysis the authors conclude that the information for the antigenic change was brought into the cell by the infecting phage and that for the formation of the antigen 34 a mechanism for the synthesis of antigen 15 is required, so that a “genetic co-operation” between the two phages occurs.
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References
Uetake, H., and Uchida, T., Virology, 9, 495 (1959).
Uetake, H., and Hagiwara, S., Virology, 13, 500 (1961).
Barksdale, L., Bact. Rev., 23, 202 (1959).
Fuchida, T., Robbins, P. W., and Luria, S. E., Biochemistry, 2, 663 (1963).
Campbell, A., Evolution, 15, 153 (1961).
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NEUBAUER, Z. Brief Consideration of the Meaning of the Lysogenic Conversion in Salmonella anatum Phage System. Nature 213, 1263 (1967). https://doi.org/10.1038/2131263a0
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DOI: https://doi.org/10.1038/2131263a0
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