Abstract
Radioactive metabolites of butter yellow (3H-dimethylaminoazobenzene) have been found to bind covalently to the liver DNA of hooded rats. The specific concentration of radioactivity dropped to roughly a half its initial value in the first 7 days and then remained roughly constant for 3 months, which implies an absence of repair. This observation could explain chromosome aberration observed in regenerating liver after treatment with carcinogens and may play a part in the latent period in the carcinogenic process.
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References
Roberts, J. J., and Warwick, G. P., Intern. J. Cancer, 1, 179 (1966).
Roberts, J. J., and Warwick, G. P., Intern. J. Cancer, 1, 573 (1966).
Phillips, D. M. P., Prog. Biophys. Chem., 12, 211 (1962).
Bucher, N. L. R., Scott, J. F., and Aub, J. C., Cancer Res., 11, 457 (1951).
McKellar, M., Amer. J. Anat., 85, 363 (1949).
Pelc, S. R., J. Cell Biol., 22, 21 (1964)
Fresco, J. R., and Bendich, A., J. Biol. Chem., 235, 1124 (1960).
Maini, M. M., and Stitch, H. F., J. Nat. Cancer Inst., 26, 1413 (1961).
Curtis, H. J., and Crowely, C., Radiat. Res., 19, 337 (1963).
Stevenson, K. G., and Curtis, H. J., Radiat. Res., 15, 774 (1961).
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WARWICK, G., ROBERTS, J. Persistent Binding of Butter Yellow Metabolites to Rat Liver DNA. Nature 213, 1206–1207 (1967). https://doi.org/10.1038/2131206a0
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DOI: https://doi.org/10.1038/2131206a0
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