Abstract
WHOLE body irradiation causes depression of haemopoiesis, and a sufficiently large dose of X-rays in an exposure of a few minutes can be effectively 100 per cent lethal. Thus, in CBA/H mice a dose of 1,000 rads results in aplastic anaemia, lethal within 2 weeks. Nevertheless, successful therapy is possible with intravenous injections of certain cell suspensions, some components of which act as seed for the recolonization of myeloid and lymphoid tissues1,2. The various cell lines, erythrocytic, granulocytic, thrombocytic and lymphocytic, may be restored by their respective precursors (polyphyletic hypothesis) or be derived by differentiation from a common multipotent cell (monophyletic hypothesis). In either case the precursor can be termed a stem cell.
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References
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BARNES, D., LOUTIT, J. Effects of Irradiation and Antigenic Stimulation on Circulating Haemopoietic Stem Cells of the Mouse. Nature 213, 1142–1143 (1967). https://doi.org/10.1038/2131142a0
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DOI: https://doi.org/10.1038/2131142a0
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