Abstract
IN recent years there has been renewed interest in the old rejected notion that rheumatoid arthritis may be caused by an infectious agent1. Highton et al.2,3 have reported rod-shaped bodies in the synovial vessels of four out of seven rheumatoid patients and two out of six patients with Reiter's disease. No such bodies were found in seven normal or near-normal synovia. These authors have therefore suggested that “these intracellular rod-shaped inclusion bodies found in endothelial cells and pericytes of synovial blood vessels may be phases of an infective agent”.
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References
Brit. Med. J., i, 607 (1965).
Highton, T. C., Caughey, D. E., and Rayns, D. G., Ann. Rheum. Dis., 25, 149 (1966).
Highton, T. C., and Rayns, D. G., Proc. Univ. Otago Med. Sch., 44, 37 (1966).
Roy, S., Ghadially, F. G., and Crane, W. A. J., Ann. Rheum. Dis., 25, 259 (1966).
Roy, S., and Ghadially, F. N., Ann. Rheum. Dis. (in the press).
Weibel, E. R., Palade, G. E., J. Cell Biol., 23, 101 (1964).
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ROY, S., GHADIALLY, F. Aetiological Significance of Rod-shaped Bodies in Rheumatoid Synovia. Nature 213, 1139–1140 (1967). https://doi.org/10.1038/2131139b0
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DOI: https://doi.org/10.1038/2131139b0
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