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Biochemical Evidence for a Distinct Type of Primary Gout

Nature volume 213, pages 1122–1123 (1967)Cite this article

Abstract

IN recent years several reports1–3 have called attention to a disorder occurring in the paediatric age group which is characterized by marked over-production of uric acid. The clinical features include haematuria and uric acid stone disease, and often, but not always, mental retardation, neurological signs, and self-mutilation. Intravenous injection of glycine-14C into such patients results in a rapid incorporation1 of isotope into urinary uric acid, signifying the presence of a shunt pathway whereby precursor is incorporated into uric acid without previous incorporation into nucleic acid purines.

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Article 26 September 2019

References

  1. Lesch, M., and Nyhan, W. L., Amer. J. Med., 36, 561 (1964).

    Article  CAS  Google Scholar 

  2. Hoefnagel, D., Andrew, E. D., Mireault, N. G., and Berndt, W. O., New Engl. J. Med., 273, 130 (1965).

    Article  CAS  Google Scholar 

  3. Rosenthal, I. M., Gaballah, S., and Rafaelson, M., Amer. J. Dis. Child., 102, 631 (1961).

    Google Scholar 

  4. Benedict, J. D., Yu, T. F., Bien, E. J., Gutman, A. B., and Stetten, jun., DeW., J. Clin. Invest., 32, 775 (1953).

    Article  CAS  Google Scholar 

  5. Sorensen, L. B., Proc. U.S. Nat. Acad. Sci., 55, 571 (1966).

    Article  ADS  CAS  Google Scholar 

  6. Sorensen, L. B., Arthritis Rheumat. (in the press).

  7. Caskey, C. T., Ashton, D. M., and Wyngaarden, J. B., J. Biol. Chem., 239, 2570 (1964).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine and the Argonne Cancer Research Hospital, University of Chicago Hospitals, Chicago, Illinois

    LEIF B. SORENSEN

  2. Department of Medicine, University of Wisconsin Medical Center, Madison, Wisconsin

    PAUL J. BENKE

Authors
  1. LEIF B. SORENSEN
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  2. PAUL J. BENKE
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SORENSEN, L., BENKE, P. Biochemical Evidence for a Distinct Type of Primary Gout. Nature 213, 1122–1123 (1967). https://doi.org/10.1038/2131122b0

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