Abstract
SEVERAL workers1–4 have shown that there are two electrophoretically and chromatographically separable forms of GOT*. These two forms are found at different sites in the cell and have different properties, and it has been shown that they are both isoenzymes of GOT. While one isoenzyme is localized in mitochondria the other is localized in the cytoplasm, and moreover, unlike the latter, the mitochondrial enzyme is markedly inhibited by its reaction product OAA.
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ZIEGENBEIN, R. Two Different Forms of Glutamic Pyruvic Transaminase in Rat Heart and their Intracellular Localization. Nature 212, 935 (1966). https://doi.org/10.1038/212935a0
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DOI: https://doi.org/10.1038/212935a0
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