Abstract
ALL the evidence at present available1 indicates that degradation of the pyridine nucleotides is the only biological source of nicotinamide, which can be formed by hydrolysis of the ribose–nicotinamide bond by enzymes of the NAD glycohydrolase (E.C. 3.2.2.5) class2. (NAD stands for nicotinamide adenine dinucleotide, and NADP for the corresponding phosphate.) An alternate route may be cleavage of NAD and NADP by nucleotide pyrophosphatases (E.C. 3.6.1.9) to produce nicotinamide mononucleotide (NMN) followed by hydrolysis. Enzymes of the NAD glycohydrolase type are highly active, almost ubiquitous in biological materials1, and may, therefore, be assumed to take the principal role in the formation of nicotinamide.
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GHOLSON, R. The Pyridine Nucleotide Cycle. Nature 212, 933–935 (1966). https://doi.org/10.1038/212933a0
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DOI: https://doi.org/10.1038/212933a0
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