Abstract
ADDITION of 1 g of cholesterol to the diet of a rabbit results in plasma lipid concentrations ten and twenty times higher than normal and in extensive lipid deposits, or atherosclerotic plaques, in the thoracic aorta within about 12 weeks (Fig. 1). Oppenheimer and Bruger first showed that simultaneous administration of cortisone inhibited plaque formation2. The inhibition is produced despite a cortisone induced increase in the dietary hyperlipaemia (Table 1)3. The mechanism of the protective effect is unknown, although it has been suggested by a number of workers that it may be related to the changes induced by cortisone in the serum lipid pattern4.
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References
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BAILEY, J., BUTLER, J. Influence of Anti-inflammatory Agents on Experimental Atherosclerosis. Nature 212, 731–732 (1966). https://doi.org/10.1038/212731a0
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DOI: https://doi.org/10.1038/212731a0
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