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Permeability Factor in Human Lymphoid Tissue

Abstract

WE recently described a permeability factor (or factors) extracted from lymph node cells of mice, rats and guinea-pigs1. This factor has been shown to be active in increasing vascular permeability, causing emigration of leucocytes2 and bringing about the deposition of a material closely resembling connective tissue fibrinoid3. It has been suggested that this material might be responsible for delayed hypersensitivity reactions in rats and guinea-pigs4,5. The present investigation was undertaken to determine whether a similar factor (or factors) was present in human lymphoid tissues.

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CAWLEY, M., WILLOUGHBY, D. Permeability Factor in Human Lymphoid Tissue. Nature 212, 705–706 (1966). https://doi.org/10.1038/212705a0

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