Abstract
IT has been demonstrated that genetic factors determine to some degree the blood pressure of rats1–3 and mice4. During the course of development of inbred strains, genes affecting blood pressure and all other traits are fixed within a strain and the strains may show differences because of the random fixation of these genes. Strains of mice with relatively low or high blood pressures are potentially useful in physiological investigations, as the genetic variability affecting the trait would be controlled within a strain. The present work was undertaken to characterize eight inbred strains of mice of diverse genetic origin with respect to systolic blood pressure.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Smirk, F. H., and Hall, W. H., Nature, 182, 727 (1958).
Okamoto, K., and Aoki, K., Jap. Circulation J., 27, 282 (1963).
Dahl, L. K., Heine, M., and Tassinari, L., Nature, 194, 480 (1962).
Schlager, G., J. Hered., 56, 278 (1965).
Henry, J. P., Meehan, J. P., Stephens, P., and Santisteban, G. A., J. Gerontol., 20, 239 (1965).
Wu, C. H., and Visscher, M. B., Fed. Proc., 6, 231 (1947).
Chevillard, L., Arnal, M., and Giono, H., C.R. Soc. Biol., 151, 276 (1957).
Fregly, M. J., J. Lab. Clin. Med., 62, 223 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SCHLAGER, G. Systolic Blood Pressure in Eight Inbred Strains of Mice. Nature 212, 519–520 (1966). https://doi.org/10.1038/212519a0
Issue Date:
DOI: https://doi.org/10.1038/212519a0
This article is cited by
-
Genetic background influences expression and function of the cation channel TRPM4 in the mouse heart
Basic Research in Cardiology (2020)
-
Sex- and age-related differences in arterial pressure and albuminuria in mice
Biology of Sex Differences (2016)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.