Abstract
RATS provide good material for the study of pulmonary carcinogens since spontaneous pulmonary tumours are very rare. They have never been observed in colonies maintained by Orr and Bielschowsky1 or by Mori2, and when Wilson et al.3 killed about 1,500 rats and carried out histological examinations on all the organs suspected of neoplasia, they did not observe pulmonary tumours.
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References
Orr, J. W., and Bielschowsky, F., Brit. J. Cancer, 1, 396 (1947).
Mori, K., Gann, 53, 303 (1962).
Wilson, R. H., DeEds, F., and Cox, A. J., jun., Cancer Res., 1, 595 (1941).
Bianciflori, C., and Ribacchi, R., Nature, 194, 488 (1962).
Bianciflori, C., Bucciarelli, E., Clayson, D. B., and Santilli, F. E., Brit. J. Cancer, 18, 543 (1964).
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BIANCIFIORI, C., GIORNELLI-SANTILLI, F., MILIA, U. et al. Pulmonary Tumours in Rats induced by Oral Hydrazine Sulphate. Nature 212, 414–415 (1966). https://doi.org/10.1038/212414b0
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DOI: https://doi.org/10.1038/212414b0
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