Abstract
WE have carried out a series of experiments intended to explain the increase in gastric secretion found in the dog when the pancreatic ducts are ligated or when all pancreatic juice is diverted to the outside. This hypersecretion was first demonstrated by Greenlee1, who transplanted a segment of duodenum containing the principal pancreatic duct into a subcutaneous position where it could drain to the outside, and then anastomosed the residual duodenum end-to-end to re-establish intestinal continuity. This gastric hypersecretion was also found by McIlrath2 when the principal pancreatic ducts were ligated. Some authors feel that this phenomenon could be explained by gastrin released from the pancreas, but we think that obstruction to the duodenum with consequent release of duodenal and antral gastrin is responsible for the increased gastric secretion observed.
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References
Greenlee, H. B., Nelsen, T. S., and Dragstedt, L. R., Surg. Forum, 10, 161 (1959).
McIlrath, D. F., Kennedy, J. A., and Hallenbeck, G. A., Amer. J. Digestive Dis., 8, 623 (1963).
White, T. T., and Magee, D. F., Surg. Gynec. Obst., 114, 463 (1962).
Emås, S., and Fyrő, B., Acta Physiol. Scand., 63, 358 (1965).
Sircus, W., Quart. J. Exp. Physiol., 43, 114 (1958).
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STACHER, G., TAY TEA, J. & WHITE, T. Gastric Hypersecretion following Intraduodenal Injection of Pancreatic Juice or Non-absorbable Antacid. Nature 212, 1607–1608 (1966). https://doi.org/10.1038/2121607a0
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DOI: https://doi.org/10.1038/2121607a0
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