Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Effect of Centrally Active Drugs on the Action of Coumarin Anticoagulants

Nature volume 212, pages 1599–1600 (1966)Cite this article

Abstract

PREVIOUS investigations have shown that pretreatment with barbiturates reduces the prothrombin response to coumarin anticoagulants, presumably by stimulating the metabolic breakdown of the coumarin drugs1. Hrdina, who was interested in the effect of centrally active drugs on the response to anticoagulants, confirmed this effect of barbiturates2. On the other hand, compounds of the morphine type were found to enhance the response to coumarins (Hrdina, personal communication), and to inhibit enzymes which metabolize drugs in the liver3. The present experiments were designed to determine whether tranquillizers or antidepressants exert an effect on the coumarin response which might correlate with the nature of their central effects.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Dayton, P. G., Tarcan, Y., Chenkin, T., and Weiner, M., J. Clin. Invest., 40, 1797 (1961).

    Article  CAS  Google Scholar 

  2. Hrdina, P., and Doualcik, V., Bratislavske Lekarske Listy, 2, 697 (1961).

    Google Scholar 

  3. Axelrod, J., Science, 124, 263 (1956).

    Article  ADS  CAS  Google Scholar 

  4. Chenkin, T., Dayton, P. G., Weisberg, L. G., and Weiner, M., Exp. Med. Surg., 17, 219 (1959).

    CAS  PubMed  Google Scholar 

  5. Greengard, P., and Quinn, G. P., Ann. N.Y. Acad. Sci., 96, 179 (1962).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. New York University Research Service, The Gold water Memorial Hospital, Welfare Island, New York

    MURRAY WEINER

Authors
  1. MURRAY WEINER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

WEINER, M. Effect of Centrally Active Drugs on the Action of Coumarin Anticoagulants. Nature 212, 1599–1600 (1966). https://doi.org/10.1038/2121599a0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2121599a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing