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Formation in vitro of a Lipoprotein Membrane masking Lysozyme Activity

Abstract

ONE of the mechanisms by which catalytic activities are regulated in cells is the segregation of enzymes by membranes. In this way, enzyme activity takes place only in a circumscribed area of the cytoplasm. Segregation clearly occurs for hydrolytic enzymes (such as lysosomal enzymes), which would otherwise act indiscriminately on cytoplasmic components.

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References

  1. Bangham, A. D., Standish, M. M., and Weissmann, G., J. Mol. Biol., 13, 253 (1965).

    Article  CAS  Google Scholar 

  2. Weissmann, G., Sessa, G., and Weissmann, S., Nature, 208, 649 (1965).

    Article  ADS  CAS  Google Scholar 

  3. Richardson, S. H., Hultin, H. O., and Fleischer, S., Arch. Biochem. Biophys., 105, 254 (1964).

    Article  CAS  Google Scholar 

  4. Romeo, D., Stagni, N., Sottocasa, G. L., Pugliarello, M. C., de Bernard, B., and Vittur, F., Biochim. Biophys. Acta (in the press).

  5. Gornall, A. G., Bardawill, C. J., and David, M. M., J. Biol. Chem., 177, 751 (1949).

    CAS  Google Scholar 

  6. Ottolenghi, A., Arch. Biochem. Biophys., 79, 355 (1959).

    Article  CAS  Google Scholar 

  7. Chen, P. S., Toribara, T. Y., and Warner, H., Anal. Chem., 28, 1756 (1956).

    Article  CAS  Google Scholar 

  8. de Duve, C., Berthet, J., and Beaufay, H., Prog. Biophys. Biophys. Chem., 9, 325 (1959).

    Article  Google Scholar 

  9. Green, D. E., Tisdale, H. D., Criddle, R. S., and Bock, R. M., Biochem. Biophys. Res. Commun., 5, 81 (1961).

    Article  CAS  Google Scholar 

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ROMEO, D., DE BERNARD, B. Formation in vitro of a Lipoprotein Membrane masking Lysozyme Activity. Nature 212, 1491–1492 (1966). https://doi.org/10.1038/2121491a0

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