Abstract
OUR earlier findings have shown that administration of adenine nucleosides or nucleotides to rats with different experimental porphyrias was followed by a decrease in excess porphyrin formation1–4. These observations have led us to the conclusion that these purine derivatives and particularly ATP play an important part in the quantitative regulation of porphyrin biosynthesis1. Moreover, it occurred to us that if this hypothesis is correct, administration of compounds capable of causing a decrease in the biosynthesis of adenosine triphosphate (ATP) might well bring about the formation of excess porphyrins and porphyrin precursors. Our observations with 6-mercapto-purine3 and orotic acid4 have confirmed this working hypothesis.
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PALMA-CARLOS, A., PALMA-CARLOS, L., GAJDOS-TÖRÖK, M. et al. Experimental Porphyria induced in Rats by Ethionine. Nature 211, 977–978 (1966). https://doi.org/10.1038/211977a0
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DOI: https://doi.org/10.1038/211977a0
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