Abstract
IN previous experiments we found that, over a wide range of doses, amphetamine and amylobarbitone affected relatively little the spontaneous activity of rats in an unfamiliar environment, but that some mixtures of these two drugs greatly increased it. This somewhat surprising effect could be regarded as a result of true mutual potentiation1,2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Steinberg, H., Rushton, R., and Tinson, C., Nature, 192, 533 (1961).
Rushton, R., and Steinberg, H., Brit. J. Pharmacol., 21, 295 (1963).
Randall, L. O., Schallek, W., Heise, G. A., Keith, E. F., and Bagdon, R. E., J. Pharmacol., 129, 163 (1960).
Bastian, J. W., Arch. Intern. Pharmacodyn., 133, 347 (1961).
Marriott, A. S., and Spencer, P. S. J., Brit. J. Pharmacol., 25, 432 (1965).
Animal Behaviour and Drug Action, edit. by Steinberg, H., de Reuck, A. V. S., and Knight, J., 429 (Churchill, London, 1964).
Carlton, P. L., Psychopharmacologia, 2, 377 (1961).
Heise, G. A., and Boff, E., Psychopharmacologia, 3, 264 (1962).
Scheckel, C. L., and Boff, E., Psychopharmacologia, 5, 198 (1964).
Weiss, B., and Laties, V. G., J. Pharmacol. Exp. Ther., 144, 17 (1964).
Rutledge, C. O., and Kelleher, R. T., Psychopharmacologia, 7, 400 (1965).
Joyce, D., and Summerfield, A., Third Intern. Pharmacol. Cong. Abstr., 54 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
RUSHTON, R., STEINBERG, H. Combined Effects of Chlordiazepoxide and Dexamphetamine on Activity of Rats in an Unfamiliar Environment. Nature 211, 1312–1313 (1966). https://doi.org/10.1038/2111312a0
Issue Date:
DOI: https://doi.org/10.1038/2111312a0
This article is cited by
-
GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior
Psychopharmacology (2010)
-
Low and high doses of midazolam differentially affect hypoalgesia in rats conditioned to a heat stressor
Psychopharmacology (1993)
-
Effect of lithium administration on rat brain 5-hydroxyindole levels in a possible animal model for mania
Psychopharmacology (1987)
-
Hyponeophagia and arousal in rats: Effects of diazepam, 5-methoxy-N,N-dimethyltryptamine, d-amphetamine and food deprivation
Psychopharmacology (1982)
-
Enhancement by chlordiazepoxide of the anticholinergic-induced locomotor stimulation in mice
Psychopharmacology (1979)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.